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Ligand-dependent Linkage of the ATP Site to Inhibition Gate Closure in the K(ATP) Channel
Major advances have been made on the inhibition gate and ATP site of the K(ir)6.2 subunit of the K(ATP) channel, but little is known about conformational coupling between the two. ATP site mutations dramatically disrupt ATP-dependent gating without effect on ligand-independent gating, observed as in...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2266580/ https://ncbi.nlm.nih.gov/pubmed/16129775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200509289 |
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