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Ligand-dependent Linkage of the ATP Site to Inhibition Gate Closure in the K(ATP) Channel

Major advances have been made on the inhibition gate and ATP site of the K(ir)6.2 subunit of the K(ATP) channel, but little is known about conformational coupling between the two. ATP site mutations dramatically disrupt ATP-dependent gating without effect on ligand-independent gating, observed as in...

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Detaylı Bibliyografya
Asıl Yazarlar: Li, Lehong, Geng, Xuehui, Yonkunas, Michael, Su, Anjey, Densmore, Erik, Tang, Pei, Drain, Peter
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2005
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266580/
https://ncbi.nlm.nih.gov/pubmed/16129775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200509289
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