Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors

BACKGROUND: Tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors. Loss of heterozygosity (LOH) at the TSC2 locus has been detected in TSC-associated renal cell c...

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Bibliografiset tiedot
Päätekijät: Habib, Samy L, Simone, Simona, Barnes, Jeff J, Abboud, Hanna E
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2008
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265742/
https://ncbi.nlm.nih.gov/pubmed/18218111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-7-10
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