The C. elegans Opa1 Homologue EAT-3 Is Essential for Resistance to Free Radicals

The C. elegans eat-3 gene encodes a mitochondrial dynamin family member homologous to Opa1 in humans and Mgm1 in yeast. We find that mutations in the C. elegans eat-3 locus cause mitochondria to fragment in agreement with the mutant phenotypes observed in yeast and mammalian cells. Electron microsco...

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Main Authors: Kanazawa, Takayuki, Zappaterra, Mauro D., Hasegawa, Ayako, Wright, Ashley P., Newman-Smith, Erin D., Buttle, Karolyn F., McDonald, Kent, Mannella, Carmen A., van der Bliek, Alexander M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265488/
https://ncbi.nlm.nih.gov/pubmed/18454199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000022
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