New Insights into Human Nondisjunction of Chromosome 21 in Oocytes

Nondisjunction of chromosome 21 is the leading cause of Down syndrome. Two risk factors for maternal nondisjunction of chromosome 21 are increased maternal age and altered recombination. In order to provide further insight on mechanisms underlying nondisjunction, we examined the association between...

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Bibliographic Details
Main Authors: Oliver, Tiffany Renee, Feingold, Eleanor, Yu, Kai, Cheung, Vivian, Tinker, Stuart, Yadav-Shah, Maneesha, Masse, Nirupama, Sherman, Stephanie L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265487/
https://ncbi.nlm.nih.gov/pubmed/18369452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000033
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