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How Protein Stability and New Functions Trade Off

Numerous studies have noted that the evolution of new enzymatic specificities is accompanied by loss of the protein's thermodynamic stability (ΔΔG), thus suggesting a tradeoff between the acquisition of new enzymatic functions and stability. However, since most mutations are destabilizing (ΔΔG&...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tokuriki, Nobuhiko, Stricher, Francois, Serrano, Luis, Tawfik, Dan S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265470/
https://ncbi.nlm.nih.gov/pubmed/18463696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000002
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