How Protein Stability and New Functions Trade Off

Numerous studies have noted that the evolution of new enzymatic specificities is accompanied by loss of the protein's thermodynamic stability (ΔΔG), thus suggesting a tradeoff between the acquisition of new enzymatic functions and stability. However, since most mutations are destabilizing (ΔΔG&...

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Detaylı Bibliyografya
Asıl Yazarlar: Tokuriki, Nobuhiko, Stricher, Francois, Serrano, Luis, Tawfik, Dan S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2008
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265470/
https://ncbi.nlm.nih.gov/pubmed/18463696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000002
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