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How Protein Stability and New Functions Trade Off

Numerous studies have noted that the evolution of new enzymatic specificities is accompanied by loss of the protein's thermodynamic stability (ΔΔG), thus suggesting a tradeoff between the acquisition of new enzymatic functions and stability. However, since most mutations are destabilizing (ΔΔG&...

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Detalhes bibliográficos
Main Authors: Tokuriki, Nobuhiko, Stricher, Francois, Serrano, Luis, Tawfik, Dan S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265470/
https://ncbi.nlm.nih.gov/pubmed/18463696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000002
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