UmuD and RecA Directly Modulate the Mutagenic Potential of the Y-family DNA Polymerase DinB

DinB is the only translesion Y-family DNA polymerase conserved among bacteria, archaea, and eukaryotes. DinB and its orthologs possess a specialized lesion bypass function but also display potentially deleterious -1 frameshift mutagenic phenotypes when overproduced. We show that the DNA damage induc...

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Huvudupphovsmän: Godoy, Veronica G., Jarosz, Daniel F., Simon, Sharotka M., Abyzov, Alexej, Ilyin, Valentin, Walker, Graham C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265384/
https://ncbi.nlm.nih.gov/pubmed/18158902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.10.025
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