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UmuD and RecA Directly Modulate the Mutagenic Potential of the Y-family DNA Polymerase DinB
DinB is the only translesion Y-family DNA polymerase conserved among bacteria, archaea, and eukaryotes. DinB and its orthologs possess a specialized lesion bypass function but also display potentially deleterious -1 frameshift mutagenic phenotypes when overproduced. We show that the DNA damage induc...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2265384/ https://ncbi.nlm.nih.gov/pubmed/18158902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.10.025 |
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