Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1(G93A) model of ALS

The potent neuroprotective activities of neurotrophic factors, including insulin-like growth factor 1 (IGF-1), make them promising candidates for treatment of amyotrophic lateral sclerosis (ALS). In an effort to maximize rate of motor neuron transduction, achieve high levels of spinal IGF-1, and thu...

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Hauptverfasser: Lepore, Angelo C., Haenggeli, Christine, Gasmi, Mehdi, Bishop, Kathie M., Bartus, Raymond T., Maragakis, Nicholas J., Rothstein, Jeffrey D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265207/
https://ncbi.nlm.nih.gov/pubmed/17963733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2007.09.034
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