Both ovarian hormones estrogen and progesterone are necessary for hormonal mammary carcinogenesis in ovariectomized ACI rats

August–Copenhagen–Irish (ACI) rats are unique in that the ovary-intact females develop high incidence of mammary cancers induced solely by hormones upon prolonged exposure to high levels of estrogen alone. Studies have also shown that such prolonged exposure to high-dose estrogen results in human-li...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Blank, Edward W., Wong, Po-Yin, Lakshmanaswamy, Rajkumar, Guzman, Raphael, Nandi, Satyabrata
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265202/
https://ncbi.nlm.nih.gov/pubmed/18299580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710535105
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