Mesenchymal–epithelial interactions involving epiregulin in tuberous sclerosis complex hamartomas

Patients with tuberous sclerosis complex (TSC) develop hamartomas containing biallelic inactivating mutations in either TSC1 or TSC2, resulting in mammalian target of rapamycin (mTOR) activation. Hamartomas overgrow epithelial and mesenchymal cells in TSC skin. The pathogenetic mechanisms for these...

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Detalhes bibliográficos
Main Authors: Li, Shaowei, Takeuchi, Fumiko, Wang, Ji-an, Fan, Qingyuan, Komurasaki, Toshi, Billings, Eric M., Pacheco-Rodriguez, Gustavo, Moss, Joel, Darling, Thomas N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265180/
https://ncbi.nlm.nih.gov/pubmed/18292222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712397105
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