Mesenchymal–epithelial interactions involving epiregulin in tuberous sclerosis complex hamartomas

Patients with tuberous sclerosis complex (TSC) develop hamartomas containing biallelic inactivating mutations in either TSC1 or TSC2, resulting in mammalian target of rapamycin (mTOR) activation. Hamartomas overgrow epithelial and mesenchymal cells in TSC skin. The pathogenetic mechanisms for these...

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Bibliografiske detaljer
Main Authors: Li, Shaowei, Takeuchi, Fumiko, Wang, Ji-an, Fan, Qingyuan, Komurasaki, Toshi, Billings, Eric M., Pacheco-Rodriguez, Gustavo, Moss, Joel, Darling, Thomas N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265180/
https://ncbi.nlm.nih.gov/pubmed/18292222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712397105
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