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Functionally significant insulin-like growth factor I receptor mutations in centenarians

Rather than being a passive, haphazard process of wear and tear, lifespan can be modulated actively by components of the insulin/insulin-like growth factor I (IGFI) pathway in laboratory animals. Complete or partial loss-of-function mutations in genes encoding components of the insulin/IGFI pathway...

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Autors principals: Suh, Yousin, Atzmon, Gil, Cho, Mi-Ook, Hwang, David, Liu, Bingrong, Leahy, Daniel J., Barzilai, Nir, Cohen, Pinchas
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265137/
https://ncbi.nlm.nih.gov/pubmed/18316725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705467105
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