The Rap–RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

The GTP-binding protein Rap1 regulates integrin-mediated and other cell adhesion processes. Unlike most other Ras-related proteins, it contains a threonine in switch II instead of a glutamine (Gln61 in Ras), a residue crucial for the GTPase reaction of most G proteins. Furthermore, unlike most other...

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Hauptverfasser: Scrima, Andrea, Thomas, Christoph, Deaconescu, Delia, Wittinghofer, Alfred
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265111/
https://ncbi.nlm.nih.gov/pubmed/18309292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.30
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