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Structural basis of an embryonically lethal single Ala → Thr mutation in the vnd/NK-2 homeodomain

The structural and DNA binding behavior is described for an analog of the vnd/NK-2 homeodomain, which contains a single amino acid residue alanine to threonine replacement in position 35 of the homeodomain. Multidimensional nuclear magnetic resonance, circular dichroism, and electrophoretic gel reta...

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Autores principales: Xiang, Bosong, Weiler, Solly, Nirenberg, Marshall, Ferretti, James A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 1998
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC22634/
https://ncbi.nlm.nih.gov/pubmed/9636163
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