StARD13(Dlc-2) RhoGap Mediates Ceramide Activation of Phosphatidylglycerolphosphate Synthase and Drug Response in Chinese Hamster Ovary Cells

To identify genes involved in etoposide drug response, we used promoter trap mutagenesis to isolate an etoposide-resistant Chinese hamster ovary (CHO) cell line. This resistant CHO-K1 line, named E91, showed cross-resistance to C(2)-ceramide (N-acetylsphingosine). The promoter trap retrovirus was fo...

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Bibliografiske detaljer
Main Authors: Hatch, Grant M., Gu, Yuan, Xu, Fred Y., Cizeau, Jeannick, Neumann, Shannon, Park, Ji-Seon, Loewen, Shauna, Mowat, Michael R.A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2008
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2262983/
https://ncbi.nlm.nih.gov/pubmed/18162584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-08-0737
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