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The use of neomycin trisulfate to inhibit enzyme-mediated glycosaminoglycan degradation in bioprosthetic heart valves

Bioprosthetic heart valves (BHVs) derived from glutaraldehyde crosslinked porcine aortic valves are frequently used in heart valve replacement surgeries. However, BHVs have limited durability and fail either due to degeneration or calcification. Glycosaminoglycans (GAGs), one of the integral compone...

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Autors principals: Raghavan, Devanathan, Simionescu, Dan T., Vyavahare, Naren R.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2262162/
https://ncbi.nlm.nih.gov/pubmed/17353047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2007.02.017
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