Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation

Nuclear factor kappa B (NF-κB) is a key mediator of inflammation. Unchecked NF-κB signalling can engender autoimmune pathologies and cancers. Here, we show that Tax1-binding protein 1 (TAX1BP1) is a negative regulator of TNF-α- and IL-1β-induced NF-κB activation and that binding to mono- and polyubi...

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Bibliografiska uppgifter
Huvudupphovsmän: Iha, Hidekatsu, Peloponese, Jean-Marie, Verstrepen, Lynn, Zapart, Grzegorz, Ikeda, Fumiyo, Smith, C Dahlem, Starost, Matthew F, Yedavalli, Venkat, Heyninck, Karen, Dikic, Ivan, Beyaert, Rudi, Jeang, Kuan-Teh
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2008
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2262037/
https://ncbi.nlm.nih.gov/pubmed/18239685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.5
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