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Negative and positive allosteric modulators of the P2X(7) receptor

BACKGROUND AND PURPOSE: Antagonist effects at the P2X(7) receptor are complex with many behaving in a non-competitive manner. In this study, the effects of N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)-5-quinolinyl]-2-tricyclo[3.3.1.1(3,7)]dec-1-ylacetamide (compound-17) and N (2)-(3,4-difluorophenyl...

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Detalhes bibliográficos
Main Authors: Michel, A D, Chambers, L J, Walter, D S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2259211/
https://ncbi.nlm.nih.gov/pubmed/18071294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707625
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