High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8(+) and CD4(+) T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high earl...

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Bibliografiske detaljer
Main Authors: Kasprowicz, Victoria, Schulze zur Wiesch, Julian, Kuntzen, Thomas, Nolan, Brian E., Longworth, Steven, Berical, Andrew, Blum, Jenna, McMahon, Cory, Reyor, Laura L., Elias, Nahel, Kwok, William W., McGovern, Barbara G., Freeman, Gordon, Chung, Raymond T., Klenerman, Paul, Lewis-Ximenez, Lia, Walker, Bruce D., Allen, Todd M., Kim, Arthur Y., Lauer, Georg M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258997/
https://ncbi.nlm.nih.gov/pubmed/18160439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02474-07
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