High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8(+) and CD4(+) T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high earl...

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Main Authors: Kasprowicz, Victoria, Schulze zur Wiesch, Julian, Kuntzen, Thomas, Nolan, Brian E., Longworth, Steven, Berical, Andrew, Blum, Jenna, McMahon, Cory, Reyor, Laura L., Elias, Nahel, Kwok, William W., McGovern, Barbara G., Freeman, Gordon, Chung, Raymond T., Klenerman, Paul, Lewis-Ximenez, Lia, Walker, Bruce D., Allen, Todd M., Kim, Arthur Y., Lauer, Georg M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258997/
https://ncbi.nlm.nih.gov/pubmed/18160439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02474-07
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