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A Chemokine-Degrading Extracellular Protease Made by Group A Streptococcus Alters Pathogenesis by Enhancing Evasion of the Innate Immune Response

Circumvention of the host innate immune response is critical for bacterial pathogens to infect and cause disease. Here we demonstrate that the group A Streptococcus (GAS; Streptococcus pyogenes) protease SpyCEP (S. pyogenes cell envelope protease) cleaves granulocyte chemotactic protein 2 (GCP-2) an...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sumby, Paul, Zhang, Shizhen, Whitney, Adeline R., Falugi, Fabiana, Grandi, Guido, Graviss, Edward A., DeLeo, Frank R., Musser, James M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258835/
https://ncbi.nlm.nih.gov/pubmed/18174342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01354-07
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