A Chemokine-Degrading Extracellular Protease Made by Group A Streptococcus Alters Pathogenesis by Enhancing Evasion of the Innate Immune Response

Circumvention of the host innate immune response is critical for bacterial pathogens to infect and cause disease. Here we demonstrate that the group A Streptococcus (GAS; Streptococcus pyogenes) protease SpyCEP (S. pyogenes cell envelope protease) cleaves granulocyte chemotactic protein 2 (GCP-2) an...

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Detalhes bibliográficos
Main Authors: Sumby, Paul, Zhang, Shizhen, Whitney, Adeline R., Falugi, Fabiana, Grandi, Guido, Graviss, Edward A., DeLeo, Frank R., Musser, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258835/
https://ncbi.nlm.nih.gov/pubmed/18174342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01354-07
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