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A Chemokine-Degrading Extracellular Protease Made by Group A Streptococcus Alters Pathogenesis by Enhancing Evasion of the Innate Immune Response

Circumvention of the host innate immune response is critical for bacterial pathogens to infect and cause disease. Here we demonstrate that the group A Streptococcus (GAS; Streptococcus pyogenes) protease SpyCEP (S. pyogenes cell envelope protease) cleaves granulocyte chemotactic protein 2 (GCP-2) an...

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Autori principali: Sumby, Paul, Zhang, Shizhen, Whitney, Adeline R., Falugi, Fabiana, Grandi, Guido, Graviss, Edward A., DeLeo, Frank R., Musser, James M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258835/
https://ncbi.nlm.nih.gov/pubmed/18174342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01354-07
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