Tumor Necrosis Factor Blockade in Chronic Murine Tuberculosis Enhances Granulomatous Inflammation and Disorganizes Granulomas in the Lungs

Tumor necrosis factor (TNF) is a prototypic proinflammatory cytokine that contributes significantly to the development of immunopathology in various disease states. A complication of TNF blockade therapy, which is used increasingly for the treatment of chronic inflammatory diseases, is the reactivat...

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Detalhes bibliográficos
Main Authors: Chakravarty, Soumya D., Zhu, Guofeng, Tsai, Ming C., Mohan, Vellore P., Marino, Simeone, Kirschner, Denise E., Huang, Luqi, Flynn, JoAnne, Chan, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258824/
https://ncbi.nlm.nih.gov/pubmed/18212087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01011-07
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