E240V Substitution Increases Catalytic Efficiency toward Ceftazidime in a New Natural TEM-Type Extended-Spectrum β-Lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens Clinical Isolates

The aim of this study was to characterize a novel extended-spectrum β-lactamase that belongs to the TEM family, the TEM-149 enzyme, and that was isolated from the urine of two hospitalized patients from different hospitals in southern Italy. The peculiarity of this enzyme was the finding of a valine...

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Bibliographische Detailangaben
Hauptverfasser: Perilli, Mariagrazia, Celenza, Giuseppe, De Santis, Francesca, Pellegrini, Cristina, Forcella, Chiara, Rossolini, Gian Maria, Stefani, Stefania, Amicosante, Gianfranco
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258539/
https://ncbi.nlm.nih.gov/pubmed/18160520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01028-07
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