Integrin α1β1 Regulates Matrix Metalloproteinases via P38 Mitogen-Activated Protein Kinase in Mesangial Cells : Implications for Alport Syndrome

Previous work has shown that integrin α1-null Alport mice exhibit attenuated glomerular disease with decreased matrix accumulation and live much longer than strain-matched Alport mice. However, the mechanism underlying this observation is unknown. Here we show that glomerular gelatinase expression,...

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Detalhes bibliográficos
Main Authors: Cosgrove, Dominic, Meehan, Daniel T., Delimont, Duane, Pozzi, Ambra, Chen, Xiwu, Rodgers, Kathyrn D., Tempero, Richard M., Zallocchi, Marisa, Rao, Velidi H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258247/
https://ncbi.nlm.nih.gov/pubmed/18258846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070473
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