Iron-Mediated Inhibition of Mitochondrial Manganese Uptake Mediates Mitochondrial Dysfunction in a Mouse Model of Hemochromatosis

Previous phenotyping of glucose homeostasis and insulin secretion in a mouse model of hereditary hemochromatosis (Hfe(−/−)) and iron overload suggested mitochondrial dysfunction. Mitochondria from Hfe(−/−) mouse liver exhibited decreased respiratory capacity and increased lipid peroxidation. Althoug...

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Autores principales: Jouihan, Hani A, Cobine, Paul A, Cooksey, Robert C, Hoagland, Emily A, Boudina, Sihem, Abel, E Dale, Winge, Dennis R, McClain, Donald A
Formato: Artigo
Lenguaje:Inglês
Publicado: ScholarOne 2008
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258172/
https://ncbi.nlm.nih.gov/pubmed/18317567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/2007-00114.Jouihan
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