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SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utili...
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| Główni autorzy: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science
2008
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2258149/ https://ncbi.nlm.nih.gov/pubmed/18335035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001759 |
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