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Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase

Thymidylate synthase (TS) is an important target of several chemotherapeutic agents, including 5-FU and raltitrexed (Tomudex). During TS inhibition, TTP levels decrease with a subsequent increase in dUTP. Uracil incorporated into the genome is removed by base excision repair (BER). Thus, BER initiat...

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Bibliografiske detaljer
Main Authors: Luo, Yuhong, Walla, Mike, Wyatt, Michael D.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258137/
https://ncbi.nlm.nih.gov/pubmed/17942376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.09.001
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