Antibody catalysis of peptidyl-prolyl cis-trans isomerization in the folding of RNase T1

An antibody generated to an α-keto amide containing hapten 1 catalyzes the cis-trans isomerization of peptidyl-prolyl amide bonds in peptides and in the protein RNase T1. The antibody-catalyzed peptide isomerization reaction showed saturation kinetics for the cis-substrate, Suc-Ala-Ala-Pro-Phe-pNA,...

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Cyhoeddwyd yn:	Proc Natl Acad Sci U S A
Prif Awduron:	Ma, Lifu, Hsieh-Wilson, Linda C., Schultz, Peter G.
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National Academy of Sciences 1998
Pynciau:	Physical Sciences
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22581/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9636134/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.13.7251
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