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Antibody catalysis of peptidyl-prolyl cis-trans isomerization in the folding of RNase T1

An antibody generated to an α-keto amide containing hapten 1 catalyzes the cis-trans isomerization of peptidyl-prolyl amide bonds in peptides and in the protein RNase T1. The antibody-catalyzed peptide isomerization reaction showed saturation kinetics for the cis-substrate, Suc-Ala-Ala-Pro-Phe-pNA,...

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Ma, Lifu, Hsieh-Wilson, Linda C., Schultz, Peter G.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 1998
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22581/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9636134/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.13.7251
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