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IgE alone promotes human lung mast cell survival through the autocrine production of IL-6

BACKGROUND: Mast cells play a key role in asthma and recent evidence indicates that their ongoing activation in this disease is mediated, in part, via IgE in the absence of antigen. In this study we have examined whether IgE alone enhances human lung mast cell (HLMC) survival. METHODS: Purified HLMC...

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Autores principales: Cruse, Glenn, Cockerill, Sarah, Bradding, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2257927/
https://ncbi.nlm.nih.gov/pubmed/18215266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-9-2
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