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Engagement of the EP(2) prostanoid receptor closes the K(+) channel K(Ca)3.1 in human lung mast cells and attenuates their migration
Human lung mast cells (HLMC) express the Ca(2+)-activated K(+) channel K(Ca)3.1, which plays a crucial role in their migration to a variety of diverse chemotactic stimuli. K(Ca)3.1 activation is attenuated by the β(2)-adrenoceptor and the adenosine A(2A) receptor through a G(s)-coupled mechanism ind...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY-VCH Verlag
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699428/ https://ncbi.nlm.nih.gov/pubmed/18792407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200738106 |
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