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Protofibril Assemblies of the Arctic, Dutch, and Flemish Mutants of the Alzheimer's Aβ(1–40) Peptide
Using a coarse-grained model of the Aβ peptide, we analyze the Arctic (E22G), Dutch (E22Q), and Flemish (A21G) familial Alzheimer's disease (FAD) mutants for any changes in the stability of amyloid assemblies with respect to the wild-type (WT) sequence. Based on a structural reference state of...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2257882/ https://ncbi.nlm.nih.gov/pubmed/18032553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.121467 |
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