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Determining the Critical Nucleus and Mechanism of Fibril Elongation of the Alzheimer's Aβ(1−)40 Peptide

We use a coarse-grained protein model to characterize the critical nucleus, structural stability, and fibril elongation propensity of Aβ(1−40) oligomers for the C(2x) and C(2z) quaternary forms proposed by solid-state NMR. By estimating equilibrium populations of structurally stable and unstable pro...

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Detalhes bibliográficos
Main Authors: Fawzi, Nicolas Lux, Okabe, Yuka, Yap, Eng-Hui, Head-Gordon, Teresa
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674024/
https://ncbi.nlm.nih.gov/pubmed/17070840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.10.011
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