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Determining the Critical Nucleus and Mechanism of Fibril Elongation of the Alzheimer's Aβ(1−)40 Peptide
We use a coarse-grained protein model to characterize the critical nucleus, structural stability, and fibril elongation propensity of Aβ(1−40) oligomers for the C(2x) and C(2z) quaternary forms proposed by solid-state NMR. By estimating equilibrium populations of structurally stable and unstable pro...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2674024/ https://ncbi.nlm.nih.gov/pubmed/17070840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.10.011 |
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