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The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1

The bryostatins are a unique family of emerging cancer chemotherapeutic candidates isolated from marine bryozoa. Although the biochemical basis for their therapeutic activity is not known, these macrolactones exhibit high affinities for protein kinase C (PKC) isozymes, compete for the phorbol ester...

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Main Authors: Wender, Paul A., DeBrabander, Jef, Harran, Patrick G., Jimenez, Juan-Miguel, Koehler, Michael F. T., Lippa, Blaise, Park, Cheol-Min, Siedenbiedel, Carsten, Pettit, George R.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC22576/
https://ncbi.nlm.nih.gov/pubmed/9618462
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