Inhibition of Tubulin Polymerization by Select Alkenyldiarylmethanes

During studies on the alkenyldiarylmethane (ADAM) class of non-nucleoside reverse transcriptase inhibitors (NNRTIs), analogues were discovered that exhibit low micromolar and sub-micromolar cytotoxicities. Since the ADAMs are structurally related to the tubulin polymerization inhibitor CC-5079, a se...

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Bibliographic Details
Main Authors:	Cullen, Matthew D., Sarkar, Taradas, Hamel, Ernest, Hartman, Tracy L., Watson, Karen M., Buckheit, Robert W., Pannecouque, Christophe, De Clercq, Erik, Cushman, Mark
Format:	Artigo
Language:	Inglês
Published:	2007
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2255563/ https://ncbi.nlm.nih.gov/pubmed/18083556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.11.114
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Inhibition of Tubulin Polymerization by Select Alkenyldiarylmethanes

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