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Synthesis and Anti-HIV Activity of New Metabolically Stable Alkenyldiarylmethane (ADAM) Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) Incorporating N-Methoxy Imidoyl Halide and 1,2,4-Oxadiazole Systems

The alkenyldiarylmethanes (ADAMs) are a unique class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) that are capable of inhibiting HIV-1 reverse transcriptase (RT) through an allosteric mechanism. However, the potential usefulness of the ADAMs is limited by the presence of metabolically...

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Bibliografske podrobnosti
Main Authors: Sakamoto, Takeshi, Cullen, Matthew D., Hartman, Tracy L., Watson, Karen M., Buckheit, Robert W., Pannecouque, Christophe, De Clercq, Erik, Cushman, Mark
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531242/
https://ncbi.nlm.nih.gov/pubmed/17579385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070236e
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