טוען...

Crystallographic Study of a Novel Sub-Nanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 (HIV-1) Reverse Transcriptase

Two crystal structures have been solved for separate complexes of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTI) 3 and 4 with HIV-1 reverse transcriptase (RT). The structures reveal inhibitor binding is exclusively hydrophobic in nature and the shape of the inhib...

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Main Authors: Cullen, Matthew D., Ho, William C., Bauman, Joseph D., Das, Kalyan, Arnold, Eddy, Hartman, Tracy L., Watson, Karen M., Buckheit, Robert W., Pannecouque, Christophe, De Clercq, Erik, Cushman, Mark
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770579/
https://ncbi.nlm.nih.gov/pubmed/19775161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901167t
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