Loading...

Crystallographic Study of a Novel Sub-Nanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 (HIV-1) Reverse Transcriptase

Two crystal structures have been solved for separate complexes of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTI) 3 and 4 with HIV-1 reverse transcriptase (RT). The structures reveal inhibitor binding is exclusively hydrophobic in nature and the shape of the inhib...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Cullen, Matthew D., Ho, William C., Bauman, Joseph D., Das, Kalyan, Arnold, Eddy, Hartman, Tracy L., Watson, Karen M., Buckheit, Robert W., Pannecouque, Christophe, De Clercq, Erik, Cushman, Mark
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770579/
https://ncbi.nlm.nih.gov/pubmed/19775161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901167t
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!