The influence of esters and carboxylic acids as the N-substituent of opioids. 1. Benzomorphans

To investigate the effects of carboxylic ester and acid moieties as the N-substituent of opioids, a short series of racemic N-substituted normetazocines was prepared. The introduction of both groups as the normetazocine N-substituent produced compounds which displayed low potency in vitro and in viv...

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Bibliographic Details
Main Authors: Metcalf, Matthew D., Aceto, Mario D., Harris, Louis S., Woods, James H., Traynor, John R, Coop, Andrew, May, Everette L.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254757/
https://ncbi.nlm.nih.gov/pubmed/17962026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.10.030
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