Pharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5,9-Dimethyl-2’-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082)

In the search for a selective delta-opioid receptor agonist, (-)-(1R,5R,9R)-5,9-dimethyl-2’-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082) and the (+)-enantiomer were synthesized and tested. (-)-NIH 11082 displayed antinociceptive activity in the paraphenylquinone test (PP...

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Autors principals: Aceto, Mario D., May, Everette L., Harris, Louis S., Bowman, Edward R., Cook, Charles D.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994320/
https://ncbi.nlm.nih.gov/pubmed/17434480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2007.03.008
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