BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia

Chronic myelogenous leukemia (CML) invariably progresses to blast crisis, which represents the most proliferative phase of the disease. The BCR-ABL1 oncogene stimulates growth and survival pathways by phosphorylating numerous substrates, including various Src family members. Here we describe up-regu...

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Bibliographic Details
Main Authors: Ban, Kechen, Gao, Yin, Amin, Hesham M., Howard, Adrienne, Miller, Claudia, Lin, Quan, Leng, Xiaohong, Munsell, Mark, Bar-Eli, Menashe, Arlinghaus, Ralph B., Chandra, Joya
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254539/
https://ncbi.nlm.nih.gov/pubmed/18180382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-091769
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