Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae

A large family of aldo-keto reductases with similar kinetic and structural properties but unknown physiological roles is expressed in the yeast Saccharomyces cerevisiae. Strains with one or two AKR genes disrupted have apparently normal phenotypes, but disruption of at least three AKR genes results...

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Bibliographic Details
Main Authors: Chang, Qing, Mark Petrash, J.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254213/
https://ncbi.nlm.nih.gov/pubmed/17919749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2007.08.008
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