Evaluation of the Langat/Dengue 4 Chimeric Virus as a Live Attenuated Tick-Borne Encephalitis Vaccine for Safety and Immunogenicity in Healthy Adult Volunteers

With the steady rise in tick-borne encephalitis virus (TBEV) infections in Europe, development of a live attenuated vaccine that will generate long-lasting immunity would be of considerable benefit. A chimeric flavivirus, designated LGT/DEN4, was previously constructed to have a genome containing th...

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Bibliografiske detaljer
Main Authors: Wright, Peter F., Ankrah, Sharon, Henderson, Susan E., Durbin, Anna P., Speicher, Jim, Whitehead, Stephen S., Murphy, Brian R., Pletnev, Alexander G.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254188/
https://ncbi.nlm.nih.gov/pubmed/18207289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2007.12.015
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