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An improved experimental system for determining small folding entropy changes resulting from proline to alanine substitutions
Changes in protein stability can be achieved by making substitutions that increase or decrease the available conformations of the unfolded protein without altering the conformational freedom of the folded protein. Matthews and coworkers (1987) proposed that proline to alanine (P → A) substitution wo...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253478/ https://ncbi.nlm.nih.gov/pubmed/16131666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051505705 |
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