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Parallel interrogation of covalent intermediates in the biosynthesis of gramicidin S using high-resolution mass spectrometry

For determination of multiple covalent intermediates bound to the ultra-large enzymes responsible for biosynthesis via nonribosomal peptide synthesis, mass spectrometry (MS) is a promising method to provide new mechanistic insight. Application of a quadrupole-Fourier-transform instrument (Q-FTMS) fo...

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Detalles Bibliográficos
Main Authors: Miller, Leah M., Mazur, Matthew T., McLoughlin, Shaun M., Kelleher, Neil L.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253301/
https://ncbi.nlm.nih.gov/pubmed/16195555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051553705
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