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The evolutionary origins and catalytic importance of conserved electrostatic networks within TIM-barrel proteins

Conservation of function is the basic tenet of protein evolution. Conservation of key electrostatic properties is a frequently employed mechanism that leads to conserved function. In a previous report, we identified several conserved electrostatic properties in four protein families and one function...

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Bibliographic Details
Main Authors: Livesay, Dennis R., La, David
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253277/
https://ncbi.nlm.nih.gov/pubmed/15840824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041221105
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