Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: No accentuation by apolipoprotein(a)

We have generated mice with markedly elevated plasma levels of human low density lipoprotein (LDL) and reduced plasma levels of high density lipoprotein. These mice have no functional LDL receptors [LDLR(−/−)] and express a human apolipoprotein B-100 (apoB) transgene [Tg(apoB(+/+))] with or without...

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Hlavní autoři: Sanan, D. A., Newland, D. L., Tao, R., Marcovina, S., Wang, J., Mooser, V., Hammer, R. E., Hobbs, H. H.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1998
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC22526/
https://ncbi.nlm.nih.gov/pubmed/9539774
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