Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: No accentuation by apolipoprotein(a)

We have generated mice with markedly elevated plasma levels of human low density lipoprotein (LDL) and reduced plasma levels of high density lipoprotein. These mice have no functional LDL receptors [LDLR(−/−)] and express a human apolipoprotein B-100 (apoB) transgene [Tg(apoB(+/+))] with or without...

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Detalhes bibliográficos
Main Authors: Sanan, D. A., Newland, D. L., Tao, R., Marcovina, S., Wang, J., Mooser, V., Hammer, R. E., Hobbs, H. H.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22526/
https://ncbi.nlm.nih.gov/pubmed/9539774
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