ATP-Bound Conformation of Topoisomerase IV: a Possible Target for Quinolones in Streptococcus pneumoniae

Topoisomerase IV, a C(2)E(2) tetramer, is involved in the topological changes of DNA during replication. This enzyme is the target of antibacterial compounds, such as the coumarins, which target the ATP binding site in the ParE subunit, and the quinolones, which bind, outside the active site, to the...

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Bibliografiske detaljer
Main Authors: Sifaoui, Farid, Lamour, Valérie, Varon, Emmanuelle, Moras, Dino, Gutmann, Laurent
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC225018/
https://ncbi.nlm.nih.gov/pubmed/14526026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.20.6137-6146.2003
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